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Cardioprotective Effects of LCZ696 (sacubitril/valsartan) After Experimental Acute Myocardial Infarction
Masanobu Ishii , Koichi Kaikita , Koji Sato , Daisuke Sueta , Koichiro Fujisue , Yuichiro Arima , Yu Oimatsu , Tatsuro Mitsuse , Yoshiro Onoue , Satoshi Araki , Megumi Yamamuro , Taishi Nakamura , Yasuhiro Izumiya , Eiichiro Yamamoto , Sunao Kojima , Shokei Kim-Mitsuyama , Hisao Ogawa and Kenichi Tsujita

Author + information

DOI:
https://doi.org/10.1016/j.jacbts.2017.08.001
Published By:
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Online ISSN:
2452-302X
History:
Copyright Usage:
2017 The Authors

Author Information

Summary

LCZ696 lowers the risk of cardiovascular events in chronic heart failure. However, it is unclear whether LCZ696 can improve prognosis in patients with acute myocardial infarction (MI). The present study shows that LCZ696 can prevent cardiac rupture after MI, probably due to the suppression of MMP-9 activity and aldosterone production, and enhancement of natriuretic peptides in mice. The present study suggests the mechanistic insight of cardioprotective effects of LCZ696 against acute MI, resulting in the beneficial effects of LCZ696 on the prognosis after acute MI in the clinical setting.

Footnotes

Funding

This study was supported in part by Novartis Pharma AG.

Disclosures

Dr Kaikita has received significant research grant support from Bayer Yakuhin, Ltd., Daiichi Sankyo Co., Ltd., Novartis Pharma AG., and SBI Pharma K.K., and has received Honoraria from Bayer Yakuhin, Ltd. and Daiichi Sankyo Co., Ltd.

Dr Ogawa has received grants from Astellas BioPharma K.K., personal fees from Astra Zeneca K.K., grants and personal fees from Bayer Yakuhin, Ltd., personal fees from Boehringer Ingelheim Japan, grants and personal fees from Bristol-Myers Squibb Co., grants and personal fees from Daiichi Sankyo Co., Ltd., grants from Dainippon Sumitimo Pharma Co., Ltd., grants and personal fees from Eisai Co., Ltd., personal fees from Kowa Co., Ltd., personal fees from Kyowa Hakko Kirin Co., Ltd., grants and personal fees from Mitsubishi Tanabe Pharma, grants and personal fees from MSD K.K., grants from Novartis Pharma K.K., grants from Otsuka Pharmaceutical Co., Ltd., grants and personal fees from Pfizer Japan Inc., grants and personal fees from Sanofi K.K., grants from Shionogi Co., Ltd., grants and personal fees from Takeda Pharmaceutical Co., Ltd., grants and personal fees from Teijin Pharma Co., Ltd., grants from Genzyme Japan K.K., grants from Kissei Pharmacetucal Co., Ltd., grants from Abbott Vascular Japan, grants from Boston Scientific Japan K.K., grants from Fukuda Denshi Co., Ltd., grants from Johnson Johnson, grants from Medtronic Japan Co., Ltd., grants from Nihon Kohden, grants from Terumo.