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A daily journal giving you insight into the life of a transgender man who will be going through high school and college. He will be juggling high school and college his junior year of college. Then he will be heading to college full time his senior year. Finally, he will attempt to graduate with a bachelor's degree at the age of twenty. He will also make an attempt to triple major in film production, Russian and English with a focus in creative writing.

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A young woman during the American Revolution hopes to find a meaningful place in the world when British Officers come to live in her home for the remainder of the war, but soon loyalties begin to blur, and life becomes more and more difficult when she discovers right and wrong, and good and evil, is not so easily reflected by the color of one's coat.

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Then, he states the true purpose of the blog -- to explain why we should "never, never ever follow in [his] footsteps." In just three sentences, this introduction has captivated us and validated the story's existence with a looming life lesson. The takeaway? Keep it short, but powerful.

Here's a great example of an introduction that presents a problem and a solution to it. Sure, it's easy to build apps on Azure, Microsoft's cloud platform -- but maybe you had some issues with its setup. Well, wouldn't you know? Azure Advisor is here to address those challenges, and you can preview it for free.

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That's a best practice for brands that have made a mistake -- even a small one. Technology is great, but it can come with bugs. That's where an intro like this one can be so helpful. It acknowledges the problem, states what the brand has done to address it, and alerts the reader to continue to learn how that solution will work.

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Here's the thing about this intro -- it gives the reader something to aspire to. We've briefly discussed aspirational marketing before, but this instance is one where it can be used in a brief introduction. After reading this first paragraph, I want to go to Tokyo. And when I'm there, I want to stay at the Mandarin Oriental. Then, I want to take in the views from its high-end sushi restaurant.

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Cardioprotective Effects of LCZ696 (sacubitril/valsartan) After Experimental Acute Myocardial Infarction
Masanobu Ishii , Koichi Kaikita , Koji Sato , Daisuke Sueta , Koichiro Fujisue , Yuichiro Arima , Yu Oimatsu , Tatsuro Mitsuse , Yoshiro Onoue , Satoshi Araki , Megumi Yamamuro , Taishi Nakamura , Yasuhiro Izumiya , Eiichiro Yamamoto , Sunao Kojima , Shokei Kim-Mitsuyama , Hisao Ogawa and Kenichi Tsujita

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LCZ696 lowers the risk of cardiovascular events in chronic heart failure. However, it is unclear whether LCZ696 can improve prognosis in patients with acute myocardial infarction (MI). The present study shows that LCZ696 can prevent cardiac rupture after MI, probably due to the suppression of MMP-9 activity and aldosterone production, and enhancement of natriuretic peptides in mice. The present study suggests the mechanistic insight of cardioprotective effects of LCZ696 against acute MI, resulting in the beneficial effects of LCZ696 on the prognosis after acute MI in the clinical setting.



This study was supported in part by Novartis Pharma AG.


Dr Kaikita has received significant research grant support from Bayer Yakuhin, Ltd., Daiichi Sankyo Co., Ltd., Novartis Pharma AG., and SBI Pharma K.K., and has received Honoraria from Bayer Yakuhin, Ltd. and Daiichi Sankyo Co., Ltd.

Dr Ogawa has received grants from Astellas BioPharma K.K., personal fees from Astra Zeneca K.K., grants and personal fees from Bayer Yakuhin, Ltd., personal fees from Boehringer Ingelheim Japan, grants and personal fees from Bristol-Myers Squibb Co., grants and personal fees from Daiichi Sankyo Co., Ltd., grants from Dainippon Sumitimo Pharma Co., Ltd., grants and personal fees from Eisai Co., Ltd., personal fees from Kowa Co., Ltd., personal fees from Kyowa Hakko Kirin Co., Ltd., grants and personal fees from Mitsubishi Tanabe Pharma, grants and personal fees from MSD K.K., grants from Novartis Pharma K.K., grants from Otsuka Pharmaceutical Co., Ltd., grants and personal fees from Pfizer Japan Inc., grants and personal fees from Sanofi K.K., grants from Shionogi Co., Ltd., grants and personal fees from Takeda Pharmaceutical Co., Ltd., grants and personal fees from Teijin Pharma Co., Ltd., grants from Genzyme Japan K.K., grants from Kissei Pharmacetucal Co., Ltd., grants from Abbott Vascular Japan, grants from Boston Scientific Japan K.K., grants from Fukuda Denshi Co., Ltd., grants from Johnson Johnson, grants from Medtronic Japan Co., Ltd., grants from Nihon Kohden, grants from Terumo.