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Fig. 7
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Altered Kv1.5 K channel protein distribution following total coronary artery occlusion. Tissue samples cryosectioned from normal, day 5, and day 14 epicardial border zone (EBZ) samples were immunostained with Kv1.5 antiserum as shown in (A, C and E), respectively. As shown in (E), there was a redistribution of Kv1.5 from the intercalated disk pattern seen in normal and day 5 EBZ tissue to a generalized cell surface pattern 14 days post coronary occlusion. (G) Antibody specificity by showing the absence of any staining at 14 days post occlusion following pre-incubation of the antisera with its appropriate fusion protein. The corresponding phase micrographs (B, D, F and H) illustrate the morphological changes in the myocytes with abundant lipid droplets (D, 5 day) or distorted shape amid a fibrous background (F and H, day 14). Bar represents 50 μM for all panels; reproduced from [50] .

Fig. 7
View large Download slide

Altered Kv1.5 K channel protein distribution following total coronary artery occlusion. Tissue samples cryosectioned from normal, day 5, and day 14 epicardial border zone (EBZ) samples were immunostained with Kv1.5 antiserum as shown in (A, C and E), respectively. As shown in (E), there was a redistribution of Kv1.5 from the intercalated disk pattern seen in normal and day 5 EBZ tissue to a generalized cell surface pattern 14 days post coronary occlusion. (G) Antibody specificity by showing the absence of any staining at 14 days post occlusion following pre-incubation of the antisera with its appropriate fusion protein. The corresponding phase micrographs (B, D, F and H) illustrate the morphological changes in the myocytes with abundant lipid droplets (D, 5 day) or distorted shape amid a fibrous background (F and H, day 14). Bar represents 50 μM for all panels; reproduced from [50] .

Repolarization of normal, lateral border and infarct zone cells in the heart with healed infarct is nonuniform. In some models, APs of different morphologies and varying degrees of prolongation (but never shortening) are found in almost all regions of the LV, especially adjacent to the infarct scar [11,12,15] .

The duration of refractoriness in infarct zone cells is consistent with the variability of AP durations. Infarct zone and lateral border cells have functional refractory periods, which often outlast the total time course of repolarization in the healed infarcted hearts [12] . Although the initial damage to lateral border zone cells may be less than that of central ischemic area cells, electrophysiological abnormalities caused by ischemia persist in the lateral border zone cells well beyond the early phase post myocardial infarction, and appear to be more severe as assessed by 50% failure to respond to a premature stimulus (reduced response) during the late phase post infarct [12] . This may imply that post-repolarization refractoriness and impaired conduction persist in the border zone fibers of healed infarcts.

If you think of stopping the growth in the foreign-born population as the unifying goal — rather than strengthening national security or promoting law enforcement — then Trump’s immigration agenda hangs together more clearly .” [emphasis added] The result of all the administration’s collective actions will be, for example, fewer immigrants coming here, including highly-skilled tech workers or even naturalized citizens not being able to bring over members of their families.

If you think of stopping the growth in the foreign-born population as the unifying goal — rather than strengthening national security or promoting law enforcement — then Trump’s immigration agenda hangs together more clearly

“Reducing the nation’s foreign-born population is also an issue the president’s allies talked about before they entered the government,” Bacon points out. He then quotes a revealing conversation that Stephen Miller had with Steve Bannon in 2016: “’It’s important to understand that historically speaking, that immigration is supposed to be interrupted with periods of assimilation and integration,’ senior Trump adviser Stephen Miller said.”

Bacon continues, “The Center for Immigration Studies — a D.C.-based think tank that describes itself as ‘low-immigration, pro-immigrant’ and has Nike Air Max Plus Tuned 1 VT Mens Shoes Court Purple 547 / Black/Reflective Silver outlet best prices discount fashionable clearance free shipping online sale 9TnxtcD2v
— and Attorney General Jeff Sessions have also buy cheap get authentic Ganter Gill Weite G Women’s Laceup Red Rot Rosso/Creme 4112 under cheap online wide range of cheap online J4gHp
the growth in the immigrant population overall.” Miller is associated with the CIS and with FAIR (Federation for American Immigration Reform), both said by organizations such as the Southern Poverty Law Center to be “hate groups.” https://fivethirtyeight.com/features/what-is-really-behind-trumps-controversial-immigration-policies/

We turn now to Steve Bannon, in an interview with Miller revealing the real motive force behind the crackdown on immigration, and the demagoguery behind such exaggerations as associating all immigrants with dangerous gangs (these appeals to fear work well for vulnerable followers of demagogues like Trump):

“You saw these guest workers,” Bannon told Miller. “You saw the CIS report yesterday. You saw that, what is it, 61 million? Isn’t’t the beating heart of this problem, the real beating heart of it, of what we gotta get sorted here, is not illegal immigration? As horrific as that is, and it’s horrific, don’t we have a problem, we’ve looked the other way on this legal immigration that’s kinda overwhelmed the country? When you look and there’s got 61 million, 20 percent of the country, is immigrants — is that not a massive problem? You were with Jeff Sessions for many, many years. Is that not the beating heart of this problem?”

We here have quoted the 2016 interview with Miller, reported in Vox . We urge our readers to study this transcript to understand Miller’s concerns over immigrants: https://www.vox.com/policy-and-politics/2017/2/2/14472404/steve-bannon-legal-immigration-problem .

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